Tyenne Infusion Therapy

See why thousands of patients choose our centers as their preferred destination for ongoing care, including Tyenne Infusion treatments.

Tyenne is a biologic therapy that is indicated to treat:

  • Moderately to severely active rheumatoid arthritis (RA) who has had an inadequate response to one or more disease-modifying anti-rheumatic drugs (DMARDs) 
  • Giant cell arteritis (GCA) 
  • Active polyarticular juvenile idiopathic arthritis (PJIA)
  • Active systemic juvenile idiopathic arthritis (SJIA)

What is Tyenne?

What Is Tyenne? 

Tyenne (tocilizumab-aazg) is an FDA-approved prescription medication administered for patients in all IVX Health centers via IV infusion. Tyenne is a biosimilar that has been FDA-approved to be as safe and effective as Actemra (tocilizumab). Tyenne is a type of medication called an interleukin-6 (IL-6) receptor antagonist and has been used to treat a variety of complex conditions by changing the way your immune system works. 

How Tyenne Works  

Tyenne works by blocking the action of a bodily protein called interleukin-6 (IL-6). This protein is believed to play a part in rheumatoid arthritis. In patients with rheumatoid arthritis (RA), this protein connects to cells and tells them to activate. When the cell activates, it may contribute to the signs and symptoms of RA. 

Tyenne Infusion Dosage & Administration

Tyenne Infusion Dosage and Administration  

Patients receive Tyenne (tocilizumab-aazg) intravenously. Treatment time for a Tyenne infusion at a medical clinic like IVX Health usually lasts roughly 60 minutes. 

Dosage and Frequency  

Your Tyenne infusion dose is based on your weight, so before every infusion you’ll be weighed. If your weight changes, you and your healthcare provider will decide if a change in dose is necessary. 

Tyenne is typically administered every four weeks. 

Administering Tyenne via IV Infusion  

  1. The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
  2. Following needle insertion, the IV line is held in place with tape. 
  3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Tyenne Side Effects

Tyenne Infusion Side Effects  

As with all medications, side effects are possible.   

The most common side effects of Tyenne include: 

  • Upper respiratory tract infections (common cold, sinus infections) 
  • Headache 
  • Increased blood pressure 
  • Injection site reactions 

Additional rarer side effects include: 

  • Serious allergic reactions including hives, rash, or flushing 
  • Nervous system problems 
  • Hepatitis B infection 
  • Cancer 
  • Liver problems (hepatoxicity) 
  • Tears or perforation of the stomach or intestines 

During and after treatment, patients need to inform their healthcare provider or nurse if they experience any serious or persistent side effects, including: 

  • Shortness of breath or trouble breathing 
  • Swelling of lips, tongue, or face 
  • Chest pain 
  • Feeling dizzy or faint 
  • Moderate to severe abdominal pain or vomiting  

Preparing for Your Tyenne Infusion

Follow these steps to prepare for your Tyenne Infusion:

Consult Your Healthcare Provider

  • Medical History Review: Ensure your healthcare provider has a complete and up-to-date medical history, including any allergies, current medications, and past reactions to Infusion.
  • Pre-Infusion Testing: Complete any required blood tests or other pre-Infusion tests as recommended by your healthcare provider.

Pre-Infusion Medications

  • Prescription Pre-Medications: Your Tyenne Infusion may require pre-medications to reduce the risk of a reaction or adverse event. Your referring provider will include any pre-medications when sending in your prescription order.
  • Instructions: Follow your healthcare provider’s instructions regarding these medications, including the timing and dosage. Take these medications about 30-60 minutes before the Infusion as directed.

Hydration and Nutrition

  • Hydrate: Drink plenty of water in the days leading up to your Infusion to ensure you are well-hydrated.
  • Eat Light: Have a light meal before your Infusion to help maintain your energy levels during the procedure.

Prepare for Comfort

  • Clothing: Wear loose, comfortable clothing with easy access to your arms for the Infusion site.
  • Entertainment: Bring something to keep you occupied, such as a book, tablet, or music, as your treatment or observation period may take several hours.

Plan for Transportation

  • Arrange a Ride: Depending on the medication and your reaction to the Infusion, you might not feel well enough to drive yourself home. Consider arranging for someone to drive you or use a ride service.

By following these steps, you can help ensure that your Tyenne Infusion is as safe and comfortable as possible. Always follow the specific instructions provided by your healthcare team.

How to Get a Referral for Tyenne

Every Tyenne Infusion referral must be accompanied by a physician’s order for treatment.

Patient information should include:

  • Name
  • Current address
  • Home and mobile phone number
  • Insurance information

Information the physician must include on the patient’s order for therapy:

  • Patient’s name and DOB
  • Order date
  • Diagnosis
  • Physician’s name and NPI#
  • Office address, phone, and fax numbers
  • Provider’s signature

Clinical documentation from the physician should include information to support a diagnosis for one or more of the following:

  • Moderately to severely active rheumatoid arthritis (RA) who has had an inadequate response to one or more disease-modifying anti-rheumatic drugs (DMARDs) 
  • Giant cell arteritis (GCA) 
  • Active polyarticular juvenile idiopathic arthritis (PJIA)
  • Active systemic juvenile idiopathic arthritis (SJIA)

If you or someone you care about has one of the conditions that Tyenne treats, IVX Health would be honored to provide your care. To find an IVX Health center near you, please click here.

Patients choose IVX Health for ongoing Tyenne treatments because:

  • ALL private suites
  • Comfortable recliners, with chairs for guests
  • Evening & weekend appointments
  • Friendly clinical staff deliver personal service
  • Big screen TVs, high-speed WiFi, free snacks

Interested in moving your care to IVX Health?

Tyenne Financial Assistance Programs

Information about financial assistance programs coming soon.

Tyenne Related Blog Posts

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The infusion experience is a tough one. So to create this serene, peaceful environment means more than you will ever know.

Jennifer, Patient at IVX Health


IVX Health would love to learn more about your care needs. If you’re interested in switching your infusion services – or if you just want to learn more – let us know.

An IVX Health team member giving a blanket to a patient