Onpattro Infusion Therapy

Onpattro is a biologic therapy that is indicated to treat:

• Hereditary ATTR (hATTR) amyloidosis

What Is Onpattro?  

Onpattro, generically known as patisiran, is a prescription infusion medication used to treat the polyneuropathy in patients suffering from hereditary ATTR amyloidosis. 

How Onpattro Works  

Patients with hereditary ATTR amyloidosis have a genetic variant causing a protein called transthyretin (TTR) to form clusters called amyloid deposits. Onpattro works by decreasing the amount of the TTR protein. This helps to decrease the number of amyloid deposits in the body and may result in fewer symptoms. 

What Is Onpattro Used For?  

Doctors order patisiran to treat: 

• Hereditary ATTR (hATTR) amyloidosis

Onpattro Infusion Dosage and Administration  

Patients receive patisiran intravenously. Treatment time for an Onpattro infusion at a medical clinic like IVX Health usually lasts around 80 minutes. 

Dosage and Frequency 

Before receiving their first intravenous infusion of patisiran, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Doses are typically administered once every three weeks. 

Administering Onpattro via IV Infusion  

1. The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Onpattro Infusion Side Effects  

As with all medications, side effects are possible.  

Common side effects include: 

• Respiratory infections, such as colds, sinus infections, and nasal congestion 
• Infusion-related reactions 

Onpattro also causes low Vitamin A levels. Your referring physician may recommend Vitamin A supplements when being treated with Onpattro. 

How To Prepare for an Onpattro Infusion  

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Onpattro IV infusion treatment at IVX Health. 

How to Get a Referral for Onpattro IV Infusions  

Every Onpattro referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Onpattro IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Supporting documentation of the diagnosis – Hereditary transthyretin-mediated (hATTR) amyloidosis. 

If you or someone you care about has one of the conditions that Onpattro infusions treat, you may want to learn more about IV infusion treatments with patisiran. To find an IVX Health infusion center near you, please click here. 

Patients chose IVX Health to receive their ongoing Onpattro treatments because:

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks