Nucala Injection Therapy

Nucala is a biologic therapy that is indicated to treat:

• Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype
• Add-on maintenance treatment of adult patients 18 years and older withchronic rhinosinusitis with nasal polyps (CRSwNP)
• The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA)
• The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause

What Is Nucala?  

Nucala (mepolizumab) is an injectable biologic monoclonal antibody used to treat patients with a variety of conditions, including severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome, and chronic rhinosinusitis with nasal polyps. 

How Nucala Works 

White blood cells called eosinophils make up a normal part of the body’s immune system. People with certain types of asthma can have too many eosinophils, leading to inflammation in the lungs and asthma attacks. 

Nucala works by reducing the number of eosinophils in the blood. 

What Is Nucala Used For?  

Doctors order mepolizumab to treat several medical conditions. 

Nucala treats: 

• Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype 
• Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP) 
• The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) 
• The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause 

Nucala Injection Dosage and Administration  

Patients receive Nucala via subcutaneous injection in the upper arm, thigh, or abdomen. 

Dosage and Frequency  

 Typical dosage is 100mg/mL. 

Injections are typically administered once every four weeks. 

Nucala Injection Side Effects  

As with all medications, side effects are possible. 

Side effects include: 

• Headache 
• Injection site reactions  
• Back pain 
• Fatigue 
• Allergic reactions

How To Prepare for a Nucala Injection 

It is essential that patients inform their physician if they: 

• Are taking oral or inhaled corticosteroids 
• Have a parasitic (helminth) infection 
• Are currently taking any other medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Nucala injection treatment at IVX Health. 

How to Get a Referral for Nucala Injections 

Every Nucala referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Nucala injection therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• List of current medications treating disease 
• Labs showing elevated eosinophil count of 150 cells/uL or higher 
• Clinicals showing number of asthma exacerbations in the last 12 months 
• FEV1 test results 
• Clinicals to support one or more of the following:
  • Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP) 
  • The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) 
  • The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause 
  • Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype

If you or someone you care about has one of the conditions that Nucala injections treat, you may want to learn more about injection treatments with mepolizumab. To find an IVX Health infusion center near you, please click here. 

Patients chose IVX Health to receive their ongoing Nucala treatments because:

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks