Nexviazyme Infusion Therapy

Nexviazyme is a biologic therapy that is indicated to treat:

• Patients 1 year of age and older with late-onset Pompe disease.

What Is Nexviazyme?  

Nexviazyme (avalglucosidase alfa-ngpt) is an enzyme replacement infusion therapy used for the treatment of patients 1 year of age and older with late-onset Pompe disease. 

How Nexviazyme Works  

Patients with late-onset Pompe disease (LOPD) lack or have a deficiency of the enzyme that breaks down glycogen in muscle cells, causing the glycogen to build up and result in muscle damage. 

Nexiazyme works by replacing the missing or deficient enzyme to bind to muscle cells and then enter the cells to help break down glycogen. 

What Is Nexviazyme Used For?  

Doctors order avalglucosidase alfa-ngpt to treat: 

• Patients 1 year of age and older with late-onset Pompe disease. 

Nexviazyme Infusion Dosage and Administration  

Patients receive avalglucosidase alfa-ngpt intravenously. Treatment time for a Nexviazyme infusion at a medical clinic like IVX Health usually lasts between four and seven hours depending on dosage amount. 

Dosage and Frequency  

Before receiving their first intravenous infusion of avalglucosidase alfa-ngpt, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Doses are typically administered once every two weeks. 

Administering Nexviazyme via IV Infusion  

1. The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Nexviazyme Infusion Side Effects  

As with all medications, side effects are possible. 

Common side effects include: 

• Headache 
• Fatigue 
• Diarrhea 
• Nausea 
• Joint pain 
• Dizziness 
• Muscle pain 
• Itching  
• Vomiting 
• Shortness of breath 
• Rash or hives 
• Tingling sensation 

How To Prepare for a Nexviazyme Infusion  

It is essential that patients inform their physician if they: 

• Have heart or lung issues 
• Have an allergy to any of the ingredients in Nexviazyme 
• Have an active or recurring infection 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Nexviazyme IV infusion treatment at IVX Health. 

How to Get a Referral for Nexviazyme IV Infusions  

Every Nexviazyme referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Nexviazyme IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Patient is 8 years and older with late (non-infantile) onset Pompe disease (GAA deficiency) who has no evidence of cardiac hypertrophy 

If you or someone you care about has one of the conditions that Nexviazyme infusions treat, you may want to learn more about IV infusion treatments with avalglucosidase alfa-ngpt. To find an IVX Health infusion center near you, please click here. 

Patients chose IVX Health to receive their ongoing Nexviazyme treatments because:

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks