Leqvio Injection Therapy

See why thousands of patients choose our centers as their preferred destination for ongoing care, including Leqvio Injection treatments.

Leqvio is a biologic therapy that is indicated to treat:

What Is Leqvio?

Leqvio is an injectable prescription medication that the Federal Drug Administration (FDA) has approved for reducing high levels of LDL-C in the blood. Leqvio reduces the amount of low-density lipoprotein cholesterol in the body by preventing the liver from producing proprotein convertase subtilisin/kexin, type 9 (PCSK9). In high amounts, this protein alters the body’s ability to remove bad cholesterol.

FDA-approved inclisiran is making a difference for men and women who continue to struggle with high cholesterol levels, including those with inherited HeFH, despite taking traditional prescription medications for lowering LDL-C.

Leqvio, explained:

Leqvio is a siRNA (small interfering RNA) that is directed to proprotein convertase subtilisin/kexin, type 9 mRNA. This PCSK9 protein can inhibit the body’s ability to remove LDL-C. Therefore, by targeting this protein and stopping its production, inclisiran injections allow for an increase in the hepatic uptake of low-density lipoprotein cholesterol, thus giving the body the ability to remove more LDL-C from the blood.

Studies indicate that when patients use inclisiran in conjunction with other cholesterol medications and while following a healthy diet, the amount of low-density lipoprotein cholesterol present in the body decreases.

What Is Leqvio Used For?

Some people have high levels of LDL-C to heterozygous familial hypercholesterolemia (HeFH), which is a genetic condition that results in an individual retaining a high LDL-C level. Unfortunately, even with cholesterol-lowering medications like statins, many of the men and women suffering with high LDL-C have yet to reach their recommended LDL-C level. Inclisiran is also used to treat people who have high cholesterol and clinical atherosclerotic cardiovascular disease (ASCVD).

Although inclisiran can help reduce the levels of low-density lipoprotein cholesterol in the body, it is unknown whether this medication can effectively decrease the risk of health problems resulting from high cholesterol (such as stroke or heart attack). More information will be available when the clinical trials studying Leqvio are completed.

Inclisiran Administration and Dosage

Leqvio is a colorless to pale yellow solution that is available in a single, pre-filled syringe. Each pre-filled syringe contains a single dose of 284 mg/1.5 mL (189 mg/mL). Healthcare professionals administer this 284 mg of inclisiran as a single, subcutaneous injection into the patient’s upper arm, thigh, or abdominal area.

Inclisiran Dosing Schedule

Following the initial 284 mg/1.5 mL injection, the patient returns in three months for a second injection of Leqvio (284 mg/1.5 mL). After these two initial injections, the patient maintains his or her cholesterol by continuing to receive inclisiran injections of 284 mg/1.5 mL every six months.

Missed Doses

If a patient misses a scheduled dose of Leqvio – and it has been less than three months since the missed dose – the regular dosing schedule resumes after the healthcare professional administers the missed dose.

If a patient misses a scheduled dose of inclisiran by more than three months, the patient’s dosing scheduling must be adjusted, returning to the initial protocol. Following the administration of the missed dose, the patient returns in three months for another dose, and then every six months thereafter.

Leqvio Side Effects

All medications have side effects. Leqvio is no different; however, inclisiran side effects are usually quite mild.

Some of the most common side effects following an inclisiran injection includes:

  • A reaction at the injection site (e.g., redness, pain, development of a rash)
  • A urinary tract infection
  • Joint pain
  • Diarrhea
  • Shortness of breath
  • Leg or arm pain
  • A chest cold

How To Prepare for a Leqvio Injection

There are no special preparation instructions to follow before an inclisiran injection. If your doctor has provided you with special instructions, be sure to follow them for the best results.

How To Get a Referral for Inclisiran(Leqvio) Injections

Every Leqvio referral must be accompanied by a physician’s order for treatment.

Patient information should include:

  • Name
  • Current address
  • Home and mobile phone number
  • Insurance information

Information the physician must include on the patient’s order for Leqvio injection therapy:

  • Patient’s name and DOB
  • Order date
  • Diagnosis
  • Physician’s name and NPI#
  • Office address, phone and fax numbers
  • Provider’s signature

Supporting clinical documentation from the physician should include:

  • Patient has to be and continue to be on Statin therapy.

More information about Leqvio injections can be found here. If you have high cholesterol despite taking prescription medications, you may want to speak with your doctor about Leqvio (inclisiran) injections. To find an IVX Health infusion center near you, please click here.

Patients chose IVX Health to receive their ongoing Leqvio treatments because:

  • ALL private suites
  • Comfortable recliners, with chairs for guests
  • Evening & weekend appointments
  • Friendly clinical staff deliver personal service
  • Big screen TVs, high-speed WiFi, free snacks

Interested in moving your care to IVX Health?

Leqvio Financial Assistance Programs

Information about financial assistance programs coming soon.

Leqvio Related Blog Posts

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The infusion experience is a tough one. So to create this serene, peaceful environment means more than you will ever know.

Jennifer, Patient at IVX Health


IVX Health would love to learn more about your care needs. If you’re interested in switching your infusion services – or if you just want to learn more – let us know.

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