See why thousands of patients choose our centers as their preferred destination for ongoing care, including Leqvio Injection treatments.
Leqvio is a biologic therapy that is indicated to treat:
What is Leqvio?
What Is Leqvio?
Leqvio is an injectable prescription medication that the Federal Drug Administration (FDA) has approved for reducing high levels of LDL-C in the blood. Leqvio reduces the amount of low-density lipoprotein cholesterol in the body by preventing the liver from producing proprotein convertase subtilisin/kexin, type 9 (PCSK9). In high amounts, this protein alters the body’s ability to remove bad cholesterol.
FDA-approved inclisiran is making a difference for men and women who continue to struggle with high cholesterol levels, including those with inherited HeFH, despite taking traditional prescription medications for lowering LDL-C.
Leqvio, explained:
Leqvio is a siRNA (small interfering RNA) that is directed to proprotein convertase subtilisin/kexin, type 9 mRNA. This PCSK9 protein can inhibit the body’s ability to remove LDL-C. Therefore, by targeting this protein and stopping its production, inclisiran injections allow for an increase in the hepatic uptake of low-density lipoprotein cholesterol, thus giving the body the ability to remove more LDL-C from the blood.
Studies indicate that when patients use inclisiran in conjunction with other cholesterol medications and while following a healthy diet, the amount of low-density lipoprotein cholesterol present in the body decreases.
Leqvio Injection Dosage & Administration
Inclisiran Administration and Dosage
Leqvio is a colorless to pale yellow solution that is available in a single, pre-filled syringe. Each pre-filled syringe contains a single dose of 284 mg/1.5 mL (189 mg/mL). Healthcare professionals administer this 284 mg of inclisiran as a single, subcutaneous injection into the patient’s upper arm, thigh, or abdominal area.
Inclisiran Dosing Schedule
Following the initial 284 mg/1.5 mL injection, the patient returns in three months for a second injection of Leqvio (284 mg/1.5 mL). After these two initial injections, the patient maintains his or her cholesterol by continuing to receive inclisiran injections of 284 mg/1.5 mL every six months.
Missed Doses
If a patient misses a scheduled dose of Leqvio – and it has been less than three months since the missed dose – the regular dosing schedule resumes after the healthcare professional administers the missed dose.
If a patient misses a scheduled dose of inclisiran by more than three months, the patient’s dosing scheduling must be adjusted, returning to the initial protocol. Following the administration of the missed dose, the patient returns in three months for another dose, and then every six months thereafter.
Leqvio Side Effects
Leqvio Side Effects
All medications have side effects. Leqvio is no different; however, inclisiran side effects are usually quite mild.
Some of the most common side effects following an inclisiran injection includes:
- A reaction at the injection site (e.g., redness, pain, development of a rash)
- A urinary tract infection
- Joint pain
- Diarrhea
- Shortness of breath
- Leg or arm pain
- A chest cold
Preparing for Your Leqvio Injection
Follow these steps to prepare for your Leqvio Injection:
Consult Your Healthcare Provider
- Medical History Review: Ensure your healthcare provider has a complete and up-to-date medical history, including any allergies, current medications, and past reactions to Injection.
- Pre-Injection Testing: Complete any required blood tests or other pre-Injection tests as recommended by your healthcare provider.
Pre-Injection Medications
- Prescription Pre-Medications: Your Leqvio Injection may require pre-medications to reduce the risk of a reaction or adverse event. Your referring provider will include any pre-medications when sending in your prescription order.
- Instructions: Follow your healthcare provider’s instructions regarding these medications, including the timing and dosage. Take these medications about 30-60 minutes before the Injection as directed.
Hydration and Nutrition
- Hydrate: Drink plenty of water in the days leading up to your Injection to ensure you are well-hydrated.
- Eat Light: Have a light meal before your Injection to help maintain your energy levels during the procedure.
Prepare for Comfort
- Clothing: Wear loose, comfortable clothing with easy access to your arms for the Injection site.
- Entertainment: Bring something to keep you occupied, such as a book, tablet, or music, as your treatment or observation period may take several hours.
Plan for Transportation
- Arrange a Ride: Depending on the medication and your reaction to the Injection, you might not feel well enough to drive yourself home. Consider arranging for someone to drive you or use a ride service.
By following these steps, you can help ensure that your Leqvio Injection is as safe and comfortable as possible. Always follow the specific instructions provided by your healthcare team.
How to Get a Referral for Leqvio
Every Leqvio Injection referral must be accompanied by a physician’s order for treatment.
Patient information should include:
- Name
- Current address
- Home and mobile phone number
- Insurance information
Information the physician must include on the patient’s order for therapy:
- Patient’s name and DOB
- Order date
- Diagnosis
- Physician’s name and NPI#
- Office address, phone, and fax numbers
- Provider’s signature
Clinical documentation from the physician should include information to support a diagnosis for one or more of the following:
If you or someone you care about has one of the conditions that Leqvio treats, IVX Health would be honored to provide your care. To find an IVX Health center near you, please click here.
Patients choose IVX Health for ongoing Leqvio treatments because:
- ALL private suites
- Comfortable recliners, with chairs for guests
- Evening & weekend appointments
- Friendly clinical staff deliver personal service
- Big screen TVs, high-speed WiFi, free snacks
Interested in moving your care to IVX Health?
Interested?
IVX Health would love to learn more about your care needs. If you’re interested in switching your infusion services – or if you just want to learn more – let us know.
