Givlaari Injection Therapy

Givlaari is a biologic therapy that is indicated to treat:

• Adults with acute hepatic porphyria (AHP)

What Is Givlaari?  

Givlaari, also known as givosiran, is a subcutaneous injection used to treat patients with acute hepatic porphyria (AHP). 

How Givlaari Works  

In people with AHP, a genetic mutation causes heme production processes in the liver to not work properly. In the liver, this process is controlled by an enzyme called aminolevulinic acid synthase 1 (ALAS1). 

When ALAS1 is activated, the heme production process is unable to keep up. This causes toxic substances called aminolevulinic acid (ALA) and porphobilinogen (PBG) to build up. 

Givlaari reduces the amount of ALAS1 in the liver, which leads to a reduction in the levels of the toxins ALA and PBG. 

What Is Givlaari Used For?  

Doctors order givosiran to treat: 

• Adults with acute hepatic porphyria (AHP) 

Givlaari Injection Dosage and Administration  

Patients receive Givlaari via subcutaneous injection. 

Dosage and Frequency  

 Before receiving their first injection of givosiran, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which they are receiving treatment. 

Injections of Givlaari are typically administered once a month. 

Givlaari Injection Side Effects  

As with all medications,  side effects are possible.  

Common side effects include: 

• Nausea 
• Injection site reactions 
• Rash 
• Changes in kidney function 
• Changes in liver function 
• Fatigue 

More serious side effects include: 

• Blood homocysteine increase 
• Chronic kidney disease 
• Device breakage 
• Fever 
• Urinary tract infections 
• Severe allergic reactions 

How To Prepare for a Givlaari Injections  

It is essential that patients inform their physician if they currently have, or have had allergies to the ingredients in Givlaari. 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Givlaari injection treatment at IVX Health. 

How to Get a Referral for Givlaari Injections 

Every Givlaari referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Givlaari injection therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Current height and weight 

If you or someone you care about has one of the conditions that Givlaari injections treat, you may want to learn more about subcutaneous injection treatments with givosiran. To find an IVX Health infusion center near you, please click here. 

Patients chose IVX Health to receive their ongoing Givlaari treatments because:

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks