Givlaari Injection Therapy

See why thousands of patients choose our centers as their preferred destination for ongoing care, including Givlaari Injection treatments.

Givlaari is a biologic therapy that is indicated to treat:

  • Adults with acute hepatic porphyria (AHP)

What is Givlaari?

What Is Givlaari? 

Givlaari, also known as givosiran, is a subcutaneous injection used to treat patients with acute hepatic porphyria (AHP). 

How Givlaari Works  

In people with AHP, a genetic mutation causes heme production processes in the liver to not work properly. In the liver, this process is controlled by an enzyme called aminolevulinic acid synthase 1 (ALAS1). 

When ALAS1 is activated, the heme production process is unable to keep up. This causes toxic substances called aminolevulinic acid (ALA) and porphobilinogen (PBG) to build up. 

Givlaari reduces the amount of ALAS1 in the liver, which leads to a reduction in the levels of the toxins ALA and PBG. 

Givlaari Injection Dosage & Administration

Givlaari Injection Dosage and Administration  

Patients receive Givlaari via subcutaneous injection. 

Dosage and Frequency  

Before receiving their first injection of givosiran, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which they are receiving treatment. 

Injections of Givlaari are typically administered once a month. 

Givlaari Side Effects

Givlaari Injection Side Effects  

As with all medications, side effects are possible.  

Common side effects include: 

  • Nausea 
  • Injection site reactions 
  • Rash 
  • Changes in kidney function 
  • Changes in liver function 
  • Fatigue 

More serious side effects include: 

  • Blood homocysteine increase 
  • Chronic kidney disease 
  • Device breakage 
  • Fever 
  • Urinary tract infections 
  • Severe allergic reactions 

Preparing for Your Givlaari Injection

Follow these steps to prepare for your Givlaari Injection:

Consult Your Healthcare Provider

  • Medical History Review: Ensure your healthcare provider has a complete and up-to-date medical history, including any allergies, current medications, and past reactions to Injection.
  • Pre-Injection Testing: Complete any required blood tests or other pre-Injection tests as recommended by your healthcare provider.

Pre-Injection Medications

  • Prescription Pre-Medications: Your Givlaari Injection may require pre-medications to reduce the risk of a reaction or adverse event. Your referring provider will include any pre-medications when sending in your prescription order.
  • Instructions: Follow your healthcare provider’s instructions regarding these medications, including the timing and dosage. Take these medications about 30-60 minutes before the Injection as directed.

Hydration and Nutrition

  • Hydrate: Drink plenty of water in the days leading up to your Injection to ensure you are well-hydrated.
  • Eat Light: Have a light meal before your Injection to help maintain your energy levels during the procedure.

Prepare for Comfort

  • Clothing: Wear loose, comfortable clothing with easy access to your arms for the Injection site.
  • Entertainment: Bring something to keep you occupied, such as a book, tablet, or music, as your treatment or observation period may take several hours.

Plan for Transportation

  • Arrange a Ride: Depending on the medication and your reaction to the Injection, you might not feel well enough to drive yourself home. Consider arranging for someone to drive you or use a ride service.

By following these steps, you can help ensure that your Givlaari Injection is as safe and comfortable as possible. Always follow the specific instructions provided by your healthcare team.

How to Get a Referral for Givlaari

Every Givlaari Injection referral must be accompanied by a physician’s order for treatment.

Patient information should include:

  • Name
  • Current address
  • Home and mobile phone number
  • Insurance information

Information the physician must include on the patient’s order for therapy:

  • Patient’s name and DOB
  • Order date
  • Diagnosis
  • Physician’s name and NPI#
  • Office address, phone, and fax numbers
  • Provider’s signature

Clinical documentation from the physician should include information to support a diagnosis for one or more of the following:

  • Adults with acute hepatic porphyria (AHP)

If you or someone you care about has one of the conditions that Givlaari treats, IVX Health would be honored to provide your care. To find an IVX Health center near you, please click here.

Patients choose IVX Health for ongoing Givlaari treatments because:

  • ALL private suites
  • Comfortable recliners, with chairs for guests
  • Evening & weekend appointments
  • Friendly clinical staff deliver personal service
  • Big screen TVs, high-speed WiFi, free snacks

Interested in moving your care to IVX Health?

Givlaari Financial Assistance Programs

Information about financial assistance programs coming soon.

Givlaari Related Blog Posts

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Jennifer, Patient at IVX Health


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