Crysvita Injection Therapy

Crysvita is a biologic therapy that is indicated to treat:

• adults and children six months of age and older with X-linked hypophosphatemia (XLH).

What Is Crysvita?  

Crysvita (burosumab-twza) is a prescription medication administered for patients in all IVX Health centers via injection to treat X-linked hypophosphatemia (XLH). 

How Crysvita Works  

 Under typical bodily conditions, a protein called fibroblast growth factor 23 (FGF23) helps maintain just the right amount of phosphorus in the body. When FGF23 is working well, the extra phosphorus the body does not need is eliminated in the urine, while the proper amount of phosphorus remains in the blood. 

For people with XLH, abnormal activity of FGF23 leads to a phosphorus deficiency within the body because too much phosphorus is being removed. Crysvita works by acting as an antibody to keep FGF23 activity in check, resulting in a normal amount of phosphorus remaining in the body. 

What Is Crysvita Used For?  

Doctors order burosumab-twza to treat:

• X-linked hypophosphatemia (XLH)

Crysvita Injection Dosage and Administration  

Patients receive burosumab-twza via subcutaneous injection. 

Dosage and Frequency  

Before receiving their first injection of burosumab-twza, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Crysvita is administered once every two weeks for children and once every four weeks for adults.  

Crysvita Injection Side Effects  

As with all medications, side effects are possible. 

Common side effects for children are: 

• Fever 
• Injection site reaction 
• Cough 
• Vomiting 
• Pain in arms and legs 
• Headache 
• Tooth infections 
• Dental cavities 
• Diarrhea 
• Decreased vitamin D levels 
• Toothaches 
• Constipation 
• Muscle pain 
• Rash 
• Dizziness 
• Nausea 

Common side effects for adults are: 

• Back pain 
• Headache 
• Tooth infection 
• Restless leg syndrome 
• Decreased Vitamin D levels 
• Dizziness 
• Constipation 
• Muscle spasms 
• Increase of phosphorus levels in the blood 
• Narrowing of the spaces within the spine 
• Pressure on the spinal cord 

How To Prepare for a Crysvita Injection  

It is essential that patients inform their physician if they: 

• Are taking oral phosphate and/or active Vitamin D  

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid before their Crysvita injection treatment at IVX Health. 

How to Get a Referral for Crysvita Injections 

Every Crysvita referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Crysvita injection therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Clinicals to support the following: 
• Patient has X-linked hypophosphatemia (XLH) 
• Patient is 6 months of age or older 

If you or someone you care about has one of the conditions that Crysvita infusions treat, you may want to learn more about IV infusion treatments with burosumab-twza. To find an IVX Health infusion center near you, please click here. 

Patients chose IVX Health to receive their ongoing Crysvita treatments because:

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks